Postdoctoral Fellow – O-GlcNAc Glycoproteomics & Neural Pathology
The Opportunity: Join the Lance Wells Lab at the CCRC at UGA to investigate the pivotal role of O-GlcNAcylation in human health and disease. This research, supported by the Michael J. Fox Foundation (MJFF) and the NIH/NICHD, focuses on the molecular mechanisms of OGT-XLID (X-linked Intellectual Disability) and the emerging links between O-GlcNAc signaling and Parkinson’s Disease. We are looking for a creative scientist to push the boundaries of how we detect and quantify this dynamic modification in the brain.
Key Responsibilities:
• Map O-GlcNAc sites and dynamics in neuronal models of Parkinson’s and OGT-XLID.
• Develop and implement advanced chemoenzymatic tagging and protein enrichment strategies.
• Conduct high-resolution mass spectrometry (LC-MS/MS) and data analysis to identify disease-specific glycoproteomic signatures.
• Generate and characterize variant cell lines and enzymes
• Investigate impact of specific changes in O-GlcNAc on key substrates
• Present and publish findings
• Grant writing
Ideal Qualifications:
• Ph.D. in Biochemistry, Chemistry, or a related field.
• Deep experience in mass spectrometry-based proteomics.
• Technical proficiency in protein purification and chemical biology labeling techniques.
Note: The Wells Lab is committed to mentorship; references from former trainees are available upon request.
About the CCRC and the Wells Lab
The Complex Carbohydrate Research Center at UGA, located in Athens GA, is a world-renowned hub for glycoscience. Postdocs in the Wells Lab benefit from a multidisciplinary environment and a culture that values both rigorous science and professional development.
How to Apply: Interested candidates should contact Dr. Lance Wells directly with a CV, a brief statement of research interests, and contact information for three references.
https://www.ugajobsearch.com/postings/477479
UGA is an Equal Opportunity/Affirmative Action employer.
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